Monday, December 23, 2019
What Are Fossil Fuels - 1922 Words
Today when our car is running low on gas, all we do is stop at a gas station and fill it up. We do not even take a second to think about it, we just do it. Not many people stop and think about how the fuel we are putting into our cars got to the gas station in the first place. The bad news for us is that oil, along with a few other resources, are fossil fuels. Almost everyoneââ¬â¢s daily life uses fossil fuels in one way or another. The big question that not many people ask or know the answer to is; what are fossil fuels? To find out what fossil fuels are, we must first know how they were formed. They were at first actual living organisms. ââ¬Å"They were formed from prehistoric plants and animals that lived hundreds of millions of years agoâ⬠(Department of Energy, N.d, p.1). Examples of fossil fuels are oil, coal, and natural gas. All three of these resources are given a term ââ¬Å"non-renewable.â⬠This is because once we use all of these resources up, they are gone forever. These non-renewable resources also cannot be replaced in our lifetime. There is only a certain amount of these fossil fuels left in the Earth for us to be able to use. To better understand fossil fuels, we need to look at each one separately. The first fossil fuel that most people think of is oil. ââ¬Å"Oil was formed from layers of sediments rich in the remains of tiny (microscopic) plants and animals. As the layers were buried deeper and deeper below younger layers of sediment, the plant and animalShow MoreRelatedWhat Are Fossil Fuels?1387 Words à |à 6 PagesStarting small I wanted to explain what fossil fuels are exactly. Also how they are non- renewable, meaning that they indeed will run out one day, and there is no way how to replenish the supply after it is gone. Fossil fuels are natural fuels such as coal or gas, these fuels formed in the geological past from the remains of microscopic plants and ancient animals like dinosaurs that lived and died mi llions of years ago. The plants and animals or (diatoms) absorbed energy that came from the biggestRead MoreWhat Are Fossil Fuels?912 Words à |à 4 Pagesabout it, we just do it. Not many people stop and think about how the fuel we are putting into our cars got to the gas station in the first place. The bad news for us is that oil, along with a few other resources, are fossil fuels. Almost everyoneââ¬â¢s daily life uses fossil fuels in one way or another. The big question that not many people ask or know the answer to is; what are fossil fuels? To find out what fossil fuels are, we must first know how they were formed. They were at first actualRead MoreWhat Can Replace Conventional Fossil Fuel?930 Words à |à 4 PagesWhat can replace conventional fossil fuel? Aviation industry has been booming over the couple of years. This would mean that the usage of fossil fuels to power the airplanes is increasing annually. Using rough calculations, it is shown that there are over 100, 000 flights flown everyday [1] . To get a clearer picture on the usage of fossil fuels used, letââ¬â¢s assume every usage of flight consumes 10,000 litres of jet fuel per day, so approximately 1 billion litres of fuel would be consumed. Over theRead MoreWhat Are Your Recommendations For Using Fossil Fuels And Renewable Energy Sources?912 Words à |à 4 Pages1. What are your recommendations for using fossil fuels and renewable energy sources? The United States currently uses approximately one quarter of the worldââ¬â¢s total energy consumption (Toossi). With around 322 million people inhabiting the United States, our population accounts for just fewer than 5% of the total world population. That means that our 5% of the worldââ¬â¢s population is using 25% of the worldââ¬â¢s energy! Something has to be done. To begin to understand why, we need to break down ourRead MoreFossil Fuels And Their Impact On The Environment862 Words à |à 4 PagesFossil Fuels and Their Impact on the Environment The amount of fossil fuels being deposited into the air should be controlled. Not only do fossil fuels pose a threat to the environment, but also to human health. The problem is not only noticeable in the depletion of human health, but also in the air, water, and land. Emissions are a concerning contribution to other problems such as global warming and greenhouse gases as well. One of the major factors of fossil fuels are vehicles. VehiclesRead MoreThe World s Dependence On Fossil Fuels1706 Words à |à 7 PagesDependence on Fossil Fuels Introduction: When you think of fossil fuels what comes to mind? Perhaps you think of the massive oil rigs set up around the world or maybe your mind wonders to how fossil fuels formed in the Earth millions of years ago. Truthfully the full extent of our usage of fossil fuels around the world is widely not realized. Around the Christmas season as you decorate your Christmas trees consider this: if your Christmas tree is artificial then it is likely manufactured with fossil fuelsRead MoreFossil Fuels ( Oil, Coal, Natural Gas )1743 Words à |à 7 Pages Fossil Fuels (Oil, Coal, Natural Gas) Debbie Burrell SCI2000 Gwynedd Mercy University Abstract Fossil fuels are non-renewable sources of energy that were form billions of years ago. The three different types of fossil fuels in the world include: oil, coal and natural gas. Although each of the three types of fossil fuels are extracted differently they are all processed and used as the worldââ¬â¢s primary sources of energy. Being the worldââ¬â¢s primary sources of energy, fossil fuel experienceRead MoreOur Impact On The Environment Essay689 Words à |à 3 Pagestrying to get what might be left, resulting in even more damage. Fossil fuels are a non-renewable source of energy, which include oil, coal, and natural gas (Ecomi, 2008). When all the fossil fuels in the Earth are used up, they cannot be replaced. They are produced out of decomposed plants and animals that date back more than six-hundred million years (Bloch, 2009). Currently, fossil fuels are being used very quickly. Almost every modern living function depends on the use of fossil fuels. WithoutRead MoreFossil Fuels And Its Effects On Our World1573 Words à |à 7 PagesFossil fuels have been a big discussion in todayââ¬â¢s world due to the pollution they have been causing on the earth. Fossil fuels have been creating energy for the world for so many years. Fossil fuels like oil, natural gas, and coals used every day by almost every American. We use it to travel, to keep us warm, to cook our food, and many other everyday activities, but we donââ¬â¢t know the harm it is doing to the world. Thanks to Media today we are starting to realize the damage fossil fuel is causingRead MoreAdvantages Of Fossil Fuels998 Words à |à 4 PagesWhat are fossil fuels? Fossil fuels are a type of gas that dominate the energy sources. Fossil fuels are one of the most used and they are starting to run out. They are mostly used due their low prices. They estimate that by the end of the 21st century fossil fuel nuclear What are fossil fuels? Fossil fuels are a type of gas that dominate the energy sources. Fossil fuels are one of the most used and they are starting to run out. They are mostly used due their low prices. They estimate that by the
Sunday, December 15, 2019
Lawrence and Dobyns Essay Revision Free Essays
The human mind is a complex and often mysterious force. While it has a great capacity for logic and reasoning, there is also a part of it that reacts in a more primal, emotional way. It not only controls what we think, but how we think, and often this can lead us to do things that we would not otherwise consider doing. We will write a custom essay sample on Lawrence and Dobyns Essay Revision or any similar topic only for you Order Now These actions can become so much the center of our thoughts that we can think of nothing else. We are forced to follow a course of action that can prove to be quite detrimental, and often even deadly. It is possible for us to convince ourselves that there is only one possible solution to a dilemma, and because of that, we can find ourselves spiraling out of control and into an abyss of destruction with little chance of steering away from it. Both ââ¬Å"Rocking Horse Winnerâ⬠and ââ¬Å"Kansasâ⬠illustrate this fact in different ways. D.H. Lawrence, in ââ¬Å"Rocking Horse Winner,â⬠uses the desire of a child, Paul, who wants desperately to gain the luck that he has been told his entire life that his parents have lacked, and in so doing help stop the whispers of a house that demands money. His mind sets on the need to acquire this luck however he must, and once he starts on the course to gain it, his fate falls into place. In his mind, gaining the luck seems to be a course for gaining his motherââ¬â¢s love instead of the sham with which he has lived his entire life. If only he can stop the whispers of the house, the ââ¬Å"hard little placeâ⬠(340) in his motherââ¬â¢s heart will dissolve and she will feel a genuine warmth and caring for her children. This hope becomes his obsession, and his mind locks on the solution that he sees, and nothing can deter him from his goals. Conversely, Stephen Dobyns, in the short story ââ¬Å"Kansas,â⬠writes about a farmer who sets his mind on the destruction of wickedness demonstrated by his wife and the man with whom she runs off. His mind is so set on this course of action that the boy who rides with him finds ââ¬Å"the strength of his resolveâ⬠(109) more frightening than the gun that lies between them. The boy perceives it as possible that the farmer will do anything to achieve his goal, and the fear that this instills him in prevents him from taking actions that, later in life, he regrets not taking. In his old age, as he is dying, his mind plays over the scene and various possible results if only the boy of so many years before had tried to steer the course of the farmerââ¬â¢s resolve in another direction. Both of these stories by D.H. Lawrence and Stephen Dobyns demonstrate the power of the human mind to make one thought overcome all others so completely that there seems to be no other resolution. The thought becomes an obsession, and, while it is possible that the obsession could be diverted, the task is a difficult one. While Paul and the farmer share the fact that their minds have resolved that they have one way, and one way only, to accomplish their goals, those goals take vastly different forms. Paul wishes to acquire something, and he reaches out with his mind into a realm of fantasy in which riding his rocking horse will help him reach his dreams and make things right. The farmer is more practical in a way, keeping his thoughts focused on a more tangible way of solving his problem. However, while Paul wishes to create, the farmer wishes to destroy. Paulââ¬â¢s desire to grab onto luck and hold on and the farmerââ¬â¢s desire to rid the world of wickedness are both quite logical in their minds, while the futility of these desires is obvious to the reader. However, those who are obsessed can rarely, if ever, realize that such futility is present. They have to learn it on their own, but too often the results of their obsession are tragic. The stories also diverge in their similarities when considering other important characters. In ââ¬Å"Rocking Horse Winner,â⬠while others are allowed to see brief glimpses of Paulââ¬â¢s obsession, no one really knows to what lengths it has gone. Bassett and Oscar only know that Paul wishes to continue to gain money for the benefit of his mother. They donââ¬â¢t see the obsession until it is too late for them to do anything about it, if such a thing is possible. However, the boy in ââ¬Å"Kansas,â⬠quickly gets insight into the obsession of the farmer. While his time is more limited during the short ride he is given, he has a chance to try and divert the farmer from his murderous goal. The task is difficult, but the possibility is there, although his fear keeps the boy from giving it more than a weak attempt. He even goes so far as to promise not to talk to the police, which takes away the one other chance that he has to put a stop to the farmerââ¬â¢s plans. This leads to a dying obsession of the old man that the boy has become to ponder all of the other possible outcomes of his encounter from so many years before. He will never know what really happened, however, and this leads to his last moments being overcome by thoughts of what might have been. Love, or perhaps the lack of love, plays a part in both stories as well. It is obvious that this emotion is what spurs the boy in Lawrenceââ¬â¢s story on to his obsession. He sees the chance to gain real love from his mother, and that chance taunts him and pulls him in to his obsession. While it is luck that he convinces himself that he really wants, and even needs, it is the lack of love from his mother that haunts him, and the desire to fill the void in himself becomes all encompassing. He effectively fools himself into thinking that luck is his great desire. In the end, perhaps he acquires his motherââ¬â¢s love, but by then it is too late. Dobyns demonstrates how love can be perverted and turned into something dark and evil. One can assume that the farmer loves his wife, but her betrayal of him, if it does not destroy that love, certainly twists it and makes him want to kill that which hurt him. He convinces himself in his mind that he is doing it to destroy the wickedness that he sees represented in this betrayal, and only by killing the objects of this wickedness will he set things right. Perhaps he believes that by destroying the object of his love he can destroy the pain that he surely feels because of the betrayal. He must ââ¬Å"stomp it outâ⬠(108) because that is what he believes he is supposed to do and he resolves that it is something that only he can do, because he is the one who was betrayed, and his wife is his own business and not that of outsiders who he likely sees as interlopers who will rob him of his final resolution. While one might write off the actions of Paul as youthful ignorance, it is more difficult to excuse the farmer. His life experience should tell him that his intended actions are wrong, but his mind finds a way to twist this knowledge and turn it into something that seems justtified and even acceptable. Paul is his own victim, but the farmer has other victims in his sights, who seem right in his mind, for he was a victim of the wickedness exhibited by his targets. So we see in these two stories the power of the mind to destroy those that it rules. It can turn thoughts into overwhelming obsessions which lead people into actions that they would not normally consider. When paired with deep emotion, the possibilities of what a person will do to feed those obsessions increase to degrees that might not seem possible to that person or those people close to him or her. How to cite Lawrence and Dobyns Essay Revision, Essay examples
Saturday, December 7, 2019
Woodstock (2737 words) Essay Example For Students
Woodstock (2737 words) Essay WoodstockWoodstock To some, the 60s were a decade of discovery as Americans first journeyed to the moon. Others remember the time as a decade of Americas moral decline with the advent of rock and roll and its representation of sinful, inappropriate ideals. Yet for many people, the 60s symbolized a decade of love and harmony. Hippies exemplified these beliefs, and in 1969 they gathered at a music festival known as Woodstock to celebrate their music, their love, and their freedom in a concert that has remained on of the most influential events of the 60s. The youth of the 60s were known as the Love generation. They made love promiscuously and openly, and preferred open to formal marriages. Weekend love-ins, free form gatherings, communal living quarters, and rock festivals were held in response to the love movement. The love movement was the hippie belief for peace and harmony. It reached its peak in the summer of 1967, and by then it had over 300,000 followers who referred to themselv es as the love children or the gentle people. They gathered in San Francisco, the hippie center of the world, during the summers. During these Summers of love, they lived on the streets of Haight-Ashbury, sitting in groups along the street and strumming their guitars (Frike 62). These love children, otherwise known as the hippies were the result of the antiwar movement that was sweeping the nation during the Vietnam war. Hippies were resolutely against the war. They participated loudly, and often violently in countless anti-war protest rallies and marches. They were known to publicly burn draft cards, and some even renounced military service for prison (Hertsgard 124). Hippies were not only antiwar, they were predominantly antiestablishment. The status symbols of their elders were decisively rejected: wealth, social position, culture, physical attractiveness, and economic security. They held in disdain, cosmetics, expensive jewelry, nightclubs and restaurants and all other refinements of the affluent society. Wealth meant nothing to them. Personal freedom to express oneself was believed to be the most important thing in life. They were antiauthority, antirace discrimination, and antipollution, in short they were rebels against the society, fighting against the moral standards of America they felt were unjust (Hertsgard 153). Events such as rock concerts soon became a platform against the repressive government and accepted morals. Such events provided opportunities to express their resentment. The rock concert of Woodstock was a prime example. It was described by psychoanalyst Rollo May as a symptomatic event of our time that showed the tremendous h unger, need, yearning for community on the part of the youth(The Big Woodstock 17). Rock concerts of the 60s had become the equivalent of a political forum for the young for the expression of political ideas, the spirit of community and awareness of the world around. Woodstock was a celebration of joy which wiped out, at least temporarily, the persistent feelings of meaninglessness that permeate our culture This concert, held in Bethel, New York, in August of 1969, has become a symbol of the 60s. It is a symbol of the hippie culture embodied in the youth of the time. This concert was the Woodstock Music and Art Fair. Billed by its youthful Manhattan promoters as An Aquarian Exposition, it promised music, peace, and great rock and roll. By a conservative estimate, more than 400,000 people, the vast majority of them between the ages of 16 and 30, showed up for the Woodstock festival. Thousands more would come if police had not blocked off access roads, which had become parking lots ch oked with stalled cars. The multitude of cars and people also forced the New York Thruway to close, creating one of the nations worst traffic jams (Peace Mecca 10). People walked as many as twenty miles to get to the concert, all the while singing songs of peace and love and carrying placards displaying their hippie sentiments. Among the many were Keep America Beautiful-Stay Stoned, Love is Power, and Flower Power. Flowers, along with a dove perched upon a guitar became the symbols of the festival. These images were painted on cars, clothes and even bodies (Rock Audience). Their shabby clothes were a symbol of their freedom, their uniforms being faded jeans and worn tee shirts. They wore beads and feathers with their long hair pulled back in bandannas and beaded headbands Had the festival lasted a little longer, as many as one million of these colorful youths might have made the pilgrimage to Bethel (What Happened 8). The lure of the festival was an all-star cast of top rock artists , including Janis Joplin, Jimi Hendrix, and Jefferson Airplane. But the good vibrations of the good groups turned out to be the least of it. What the youth of America, and their observing elders saw at Bethel was the potential power of a generation that had in countless disturbing ways rejected the traditional values and goals of the U.S. Thousands of young people, who had previously thought of themselves as an isolated minority realized now what power they had as a group over society (Fass 3). Woodstock was the brainchild of four young entrepreneurs who wanted to put on a great Rock and Roll show for America In 1968, the four men, Michael Lang, Artie Kornfield, Joel Rosenman, and John Roberts, made a visit to their friend Max Yasgur who lived on a farm near Bethel, New York. They had chosen the town of Bethel for their concert because of the symbolic biblical reference in its name. The four managed to convince Yasgur to let them hold their concert on his 600-acre farm. He agreed to the estimate that only ten to fifteen-thousand people would be attending the concert on his land (Woodstock Music). Hobby And Sport EssayDespite the religious pressures, rock music flourished in England, as did the music scene in the U.S. San Francisco immediately became the heart of it. Known as the Liverpool of the West, San Francisco was bursting with rock activity in the 60s. Embedded in this citys rock scene were such groups as the Grateful Dead, Sly and the Family Stone, and the Byrds. The music of these groups began the infamous Acid Rock movement. It symbolized and portrayed the drug abuse of the decade. The widespread use of mind altering drugs such as marijuana and LSD provided the inspiration for the creation of this music (Grunwald 254). The music of the sixties was diverse and colorful in its nature. The different sounds of sixties rock included folk, reggae, acid, blues, soul, punk, and countless others that helped shape the music of this period. Compared to the fifties, it had become subtler and more sophisticated. Songs of this decade reached for the poetic, the symbolic, and the mystical in an effort to better pinpoint the moods of the times. Through such varied means, rock music became an art that appealed to the youth of America This music provided a support during the turbulent times of the sixties. It stood firmly while the mushroom cloud of the atom bomb and the smoke from the devastation in Vietnam hung menacingly over America, and it remained a support throughout the antiwar movement which deeply involved the young. In revolt to the war, the youth of America had become flower children, or hippies. They rebelled against a society whose morals they held in disdain. They symbolized the universal need for love and harmony. Finding an outlet in music, they created songs that expressed their need for personal freedom and societal peace crying out to give peace a chance (Hertsgard 309). The music festival of Woodstock was a prominent event of their time that was viewed as a celebration of life in the sixties, during which Hundreds of thousands of kids cam e together to enjoy each other in the presence of music, and of peace. They knew about art and nature. They lived for a weekend in the still eye of the hurricane (Woodstock). BibliographyWorks CitedAll Nature is but Art: Woodstock Music and Art Fair. Vogue. December 1969:194-201. Big Woodstock Rock Trip. Time. August 1969:14b-22. Ewen, David. All the Years of Popular Music. New Jersey: Prentice-Hall Inc.,1977. Fass, Don. The Sixties. http://www.sixties.net (19 March 1999). Frike, David. Minor Epiphanies and Momentary Bummers. Rolling Stone. August 1989:62-91. Grunwald, Henry. Youth Trip. This Fabulous Century: 1960-1970. 1986 ed. Hertsgard, Mark. A Day in the Life: The Music and Artistry of the Beatles. New York: Dell Publishing Groups Inc.,1995. Huges, Rupert. Music Lovers Encyclopedia. New York: Doubleday Inc.,1984. Rock Audience Moves to Dusk-to-Dawn Rhythms. New York Times. 18 August 1969:25. Tired Rock Fans Begin Exodus From Music Fair. New York Times. 20 August 1969:1-3. What Happened in the Sixties?. http://www.bbhq.com/sixties2.htm (19 March 1999). Woodstock: Dawn of the Bigtime. Economist. August 1989:75. Woodstock Music and Art Fair. Newsweek. August 1969:88. Woodstock: Peace Mecca. Billboard. August 1969:1,10. Music Essays
Saturday, November 30, 2019
Social Change and the Role of Environmental Factors
Table of Contents Introduction Types of Environmental Forces Resources Disasters or calamities Climatic Changes Degradation of environment References Introduction Environmental forces are factors that affect the growth, operations and survival of a society within a given context. They include the political environment in a society, its cultural beliefs, government regulations, changes in technology, natural disasters and demography factors among others (Charles and Steg, 2007).Advertising We will write a custom essay sample on Social Change and the Role of Environmental Factors specifically for you for only $16.05 $11/page Learn More The purpose of this paper is to discuss the five major environmental factors that impact on social changes within a society. In order to understand how environmental factors influence the society it is necessary that we understand what the concept of social change entails. Social change refers to the alteration or change in the social order of a given society or group of people especially with regard to nature, relationships, behavioral patterns in the society and the social institutions that define them. Social change is also used to refer to progress achieved by the society through evolution and revolution that may have been undertaken by members of that society. Types of Environmental Forces From time to time, any society will always experience some changes that will bring about alterations of the community settings that influence the activities that the society is engaged and its performance in general. The following are environmental factors that bring about social change in a society or group of people. Resources The amount and type of resources available to a given society will play a significant role in promoting social change (Crompton Kasser, 2010). Examples of vital resources include water, land and minerals among others which are used in the production of goods and services. The availa bility of such resources will determine to a great extent the level of production and output the society has. If factors of production such as land, labour, capital and entrepreneurship are readily available, the production capacity of a society will definitely be high which implies potential for a stable economy. In this regard, goods and services will be readily available for sale in the market and employment opportunities will be created where people have constant source of income which will improve the overall living standards of the people. This will therefore lead to a social change that is positive as the lifestyle of people in the society will improve. On the other hand, if there are limited resources in a society, there will be stiff competition for them as everyone will be competing for these limited resources thereby leading to potential outbreaks of conflicts among members of the society. This will possibly lead to depletion of the resources which could bring about more conflicts in the society. Therefore, as we have seen availability of resources in a community plays a significant role in determining whether the social change that takes place is positive or negative.Advertising Looking for essay on social sciences? Let's see if we can help you! Get your first paper with 15% OFF Learn More Disasters or calamities Natural calamities and disasters will influence to a great extent the nature of social change that occurs in a society. Hunger, earthquakes and civil war usually adversely affect a society in that it leads to displacements, migrations, change in lifestyle of the people and even loss life. During such cases, people are forced to adapt to new ways of life like constructing new homes, relocating to other places and coming up with new methods of sustenance in order to revert to the original way of life. In most cases, natural calamities usually bring about negative impacts and change in the society while in other cases, people ge t to reorganize themselves on a more solid foundation while they draw lessons from the calamity to better prepare for the future. In such a situation, the natural disasters will have promoted social change. A good example is seen when flooding takes place, in such cases some people have their homes swept away and as a result new and better homes are built elsewhere where flooding is unlikely to occur. In that case environmental forces have social change for the better. Climatic Changes In recent times, the climatic conditions have become quite unpredictable which has adversely affected farming activities globally. This is a serious concern given that farming as an economic activity especially in the developing countries forms the back-bone of the economy. Most often, such countries rely on agricultural exports as their source of income and therefore large proportion of citizens in such countries practice farming both on small scale and large scale. This implies that much of their in vestment centers on farming and in the event of unexpected weather patterns like short or excessive rains the entire produce might eventually fail. On the other hand, if the climatic patterns become predictable farmers will be able to invest more into farming without fear as they know that they will reap much. Some of the produce can then be used for domestic consumption while the surplus can be sold to generate income hence improving the living standards of the society. Degradation of environment Severe environmental degradation will lead to change in the lifestyle of people around it as it affects them negatively. Incidences of air pollution, land pollution and water pollution are most often seen to directly affect the health of the people leading to such diseases like breathing complications and water related diseases (Massicotte, 2009). This can at times trigger mass protests of the community members who might decide to demonstrate against such cases of environmental pollution. In conclusion therefore social change is seen to be caused by all of the above listed factors as well as others not discussed in this paper.Advertising We will write a custom essay sample on Social Change and the Role of Environmental Factors specifically for you for only $16.05 $11/page Learn More References Charles, V Steg, L. (2007) Environmental Psychology. Journal of Social Issues, 63Ã (1): 1-19. Crompton, T Kasser, T. (2010). Social Aspects. Journal of Environment, 52 (4): 23- 33. Massicotte, M. (2009). Activism. Globalizations, 6 (4): 411-431. Reuveny, R. (2009). Environmental Degradation. Social Science Quarterly, 90 (3): 461-479. This essay on Social Change and the Role of Environmental Factors was written and submitted by user Analia Benton to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.
Tuesday, November 26, 2019
How to beat distraction, the new writers block - Emphasis
How to beat distraction, the new writers block How to beat distraction, the new writers block Writers block used to mean sitting at your desk, staring into the empty void that was your screen and hoping for inspiration. Ah, those were the days. Now its not emptiness but a world crammed with tempting morsels thats the problem. Gone is the blank screen. In its place is an infinite variety of distractions, each way more enticing than not just writing but even thinking about writing. Half the problem is the very place where you write your documents ââ¬â your computer. Because thats where most of the distractions are. Even the best ideas stand helpless against an onslaught of instant messages, notifications, Google searches and browser tabs (each of which can easily lead you to the other, forming a complex loop that quickly fills your head with a kind of digital fug). I never thought Id feel nostalgic for plain vanilla writers block. But in the era before the web got its spindly filaments into every part of our lives, at least you could identify and isolate the problem. Maybe it was fear of failure. Perhaps a lack of ideas. These days, concentrating for more than a few minutes is a challenge in itself. Trying to join two ideas together takes near super-human focus. Fortunately, I think I may have discovered the solution. And focus is at its core. Its an online course called Focused Every Day, from the author David Levin. (You can try a free version of the programme here.) Ive actually tried this course and it worked for me. In fact, Id say its one of the most effective programmes Ive followed in a long, long time. (To put the recommendation in context, this is the first time in our 15-year history that weve endorsed a course from someone else.) Its improved my own focus many-fold, with the result not only that ideas have begun to flow again but that Ive been able to capture and act on them. Its made distraction much, much easier to control and dramatically improved my own business-writing output. So, why does it work? I think its because Levin has taken some very simple yet powerful concepts and made them incredibly easy to apply. Its a deceptively straightforward course. This and the authors gentle, engaging delivery are its great strengths. Its such a refreshing change from, say, books that require you to memorise intricate concepts or change your entire approach to everyday life. I strongly urge you to give it a go. Sign up for the free training videos here.
Friday, November 22, 2019
A View of How Elizabeth Cady Stanton Was Instrumental In Pushing Forward the Right for Women to Vote
A View of How Elizabeth Cady Stanton Was Instrumental In Pushing Forward the Right for Women to Vote Womenââ¬â¢s rights movement is the most important event that happens a long time ago since the day all men take over in every area such as decisions, jobs, the stands in society, etc. Many activists have stood up for their own rights such as the womenââ¬â¢s rightssuch as Susan B. Anthony, Alice Paul, Lucy Stone, and Ida B. Wells. Elizabeth Cady Stanton is one of those who stand up for the war of womenââ¬â¢s rights. Shewrites a draft, ââ¬Å"Declaration of Sentiments and Resolutions, Seneca Falls Convention, 1848,â⬠to providethe limitations women face during that time; she feels women deserve those rights. Afterwards, the womenââ¬â¢s rights have been approved, but many wrongs have yet to be addressed since the 19th Century such as denying women the right to vote, denying women the right to work in profitable employment by monopolizing jobs and banning women from working in theology, medicine, and law, and creating and perpetuatinga system of dependency that causes wo men to lose self-respect and confidence different moral codes for both men and women in her arguments. Elizabeth Cady Stanton points out how men and society reject women to vote. She writes a list of many wrongs to women in the Declaration of Sentiments and Resolutions, Seneca Falls Convention, 1848, which takes place in New York, on Nolo website with the article, ââ¬Å"He has never permitted her to exercise her inalienable right to the elective franchise.â⬠Elizabeth Cady Stanton is one of the very first activists for the womenââ¬â¢s rights. She involves in the womenââ¬â¢s rights movement from 1815 to 1902. She writes the Declaration of Sentiment and Resolutions, Seneca Falls Convention, 1848, as a draft to the Government seeking approval to amend the United States of America Constitution. No one sees anything wrong with a female stands up and speaks out loud about her thoughts or vote and elect whomever they want for any of the elections. Denying women the right to work in profitable employment by monopolizing jobs and banning women from working in theology, medicine and law is the second point in the abuse lists that Elizabeth Cady Stanton throws out for proving the most significant defections such as this following statement in her Declaration of Sentiments and Resolutions, Seneca Falls Convention, 1848, ââ¬Å"He has monopolized nearly all the profitable employments, and from those she is permitted to follow, she receives but a scanty remuneration. He closes against her all the avenues to wealth and distinction, which he considers most honorable to himself. As a teacher of theology, medicine, or law, she is not known.â⬠Historically, womenââ¬â¢s roles include maintaining the entire household, but in modern day times, women deserve the right to work as men because they born equally and work with their strongest power as men. Women find the right rights to earn or receive and gain back everything as men in wor k places. Base on an article of Victor Tembo in Linked in website, he says: ââ¬Å"The EU has attempted to provide leadership on issues of Gender by making gender equality as a primary objective in the various projects. Sadly, in 2012, only 28 percent of new EU project proposals had gender as a primary or significant objective, far below the target of 80 percent for 2015. Luckily however, consensus is growing around the need to demonstrate more sturdy leadership to ensure that gender equality and womenââ¬â¢s empowerment stay visible and high on the agenda.â⬠He also states out: ââ¬Å"I have a vision that one day, the world especially in the developing countries, will look at women as significant contributors to the GDP of a country and to the well being of not just their families but society as a whole. I have a vision that within 5 years from today, there shall be a significant improvement in the numbers of women leaders at various levels (a situation which can be guarante ed if the rights of women are properly institutionalized within policies of organizations). My belief is that the attitudes and expectations surrounding gender roles are typically based not on any inherent or natural gender differences, but on stereotypes, or overgeneralizing about the attitudes, traits, or behavior patterns of women or men. Its admirable how the western countries have developed in all fields of life. Their education system, their health care system, information technology etc., are in the highest rankings. In western countries men and women are working shoulder to shoulder in the same pace and both are contributing and playing their parts equally in the developmental processes. They are given basic education as well as fundamental and higher education without any restrictions from the society. Early pregnancies or early marriages that are prevalent in Africa and have stopped many African girls becoming relevant in society are unheard of. That is why the West is tha t much developed. They are educating and encouraging both the sexes equally without discriminating or neglect of the girl child. In this way,there is competition and where there is competition there is invention and invention leads to massive development in one way or another.â⬠The last point that Elizabeth Cady Stanton mentions is about creating and perpetuatinga system of dependency that causes women to lose self-respect and confidence different moral codes for both men and women in her Declaration of Sentiments and Resolutions, Seneca Falls Convention, 1848. Therefore, these next following statements speak up the full meanings of how the society and men treat women back in the days in every area: ââ¬Å"He has created a false public sentiment by giving to the world a different code of morals for men and women, by which moral delinquencies which exclude women from society are not only tolerated but deemed of little account in man.â⬠And, ââ¬Å"He has endeavored, in every way that he could, to destroy her confidence in her own powers, to lessen her self-respect, and to make her willing to lead a dependent and abject life.â⬠If men can do it, then women can do it, too. He, or no one needs to calculate or spend time to do any separations or compar isons in every situation between men and women. According to the Declaration of Sentiments and Resolutions, Seneca Falls Conventions, 1848 of Elizabeth Cady Stanton writes as a draft in New York for fighting for the womenââ¬â¢s right movement to get the approval from the United States of America Constitution for being one of the amendments. Elizabeth Cady Stanton and Susan B. Anthony are the founders of the Womenââ¬â¢s Loyal National League in 1863 and they initiate the American Equal Rights Association in 1866, which campaign the rights for women and African Americans. They post the newspapers about the Women Suffrage and fight for them in years after that. Elizabeth Cady Stanton talks about how women get treated by men and society as non-human with no voices and choices since 1800s to the 19th Century. It seems women do not deserve anything like that. Why does the society make women live in no voices, choices and stay under menââ¬â¢s? Women are born equally as men. So, they deserve everything as men do. That means, they deserve the rights to vote, to speak, to work, to do anything they want as men, even for awhile much has changed for women since the 19th Century, many wrongs have yet to be addressed such as such asdenying women the right to vote, denying women the right to work in profitable employment by monopolizing jobs and banning women from working in theology, medicine, and law, and creating and perpetuatinga system of dependency that causes women to lose self-respect and confidence different moral codes for both men and women in her Sentiments to the Government and the world out there to stay on the right side.
Wednesday, November 20, 2019
Monsanto Company by Their Patent Agent, De Penning and Depen v Case Study
Monsanto Company by Their Patent Agent, De Penning and Depen v. Coramandal Indag Products LTD - Case Study Example Monsanto filed a lawsuit in India seeking both injunctive relief and an account for the infringement of its patents. The trial court decreed and the case was subsequently dismissed by the appellate court. The appellate court, however, certified the case to the Indian Supreme Court on the basis that substantial and complex questions of law were involved. On review, the Supreme Court disagreed that the questions were substantial, but nonetheless accepted the case to identify and to clarify the real issues presented by the underlying facts. The questions presented are essentially twofold with some subsidiary issues. The first question is whether Monsanto held a patent. The Supreme Court held that there was no patent. A second issue was whether, under the Patents Act 1970, the defendant had a basis to revoke a patent. This issue was comprised of two further issues. First, under section 64(e) of the Patents Act of 1970, was this process generally known and therefore subject to revocation The Supreme Court found that this process was generally known. Second, under section 64(1)(f) of the Patents act of 1970, did Monsanto extend and improve this known process by some "inventive step" The Supreme Court found no evidence of an inventive step and held that revocation was justified in any event. Ã
Tuesday, November 19, 2019
INTERNATIONAL POLITICAL ECONOMY Essay Example | Topics and Well Written Essays - 1500 words
INTERNATIONAL POLITICAL ECONOMY - Essay Example To this date, the islands are semi-autonomous with their own president and legislature and are mainly inhabited by Arabs and Africans with Islam as the main religion (Cunningham, 2010). Tanzaniaââ¬â¢s first president was Julius Nyerere who led a single party state and nationalized all core industries and formed Ujamaa. This was a rural-based collective movement of African socialism and self-reliance (Tripp, 1997). The movement faced increasing popular discontent and was slowly abandoned in the 1980s (Green, 2003). Nyerere was succeeded by Ali Mwinyi. Under Mwinyiââ¬â¢s leadership, the country underwent various reforms and a slow and gradual transition to a market economy, partly due to economic downturn brought on by Ujamaa and centralized economic management (Tripp, 1997). Tanzaniaââ¬â¢s Economy Tanzaniaââ¬â¢s economy depends greatly on agriculture, which accounts for 50% of GDP of which 10% is contributed by livestock (Cunningham, 2010). Agriculture accounts for 85% of Tanzaniaââ¬â¢s exports and employs more than 80% its working population (Cunningham, 2010). Topography and climatic conditions however, limit cultivated crops to merely 4% of the total land area (Green, 2003). The Industrial sector is mainly characterized by processing of agricultural goods and light consumer products. Currently, Breton wood institutions and international donors have offered funds to revitalize the countryââ¬â¢s obsolete economic infrastructure and reduce poverty. Growth in the last two decades characterized a lift in industrial production and a considerable rise in output of minerals led by gold (Cunningham, 2010). Current banking reforms have also facilitated an increase in private sector growth and investment (Green, 2003). Sustained donor aid and sound macroeconomic trade policies and regulations supported real GDP growth to around 6.4% annually in 2010 as noted by Cunningham (2010). The populace of Tanzania is concentrated along the coast region and islan ds, the fertile northern and southern highlands as well as areas bordering Lake Victoria. The arid and semi-arid central region is sparsely concentrated (Buchert, 1994). Likewise is much of the fertile and well watered far west, comprising of the shores of Lake Tanganyika and Lake Malawi. Nearly, 80% of its population lives in rural communities (Green, 2003). Tanzaniaââ¬â¢s Educational sector Tanzania recognizes the role of the education sector in realizing the overall growth and development goal of enhancing living standards of its citizens. Numerous policy and structural reforms have been started in the country to enhance quality of education and ensure universal primary education for all (Cunningham, 2010). Abolition of primary school fees through PRS1 was the first step toward this goal. This was to reinforce the relationship between education offered at all levels and the socio-economic development of the country (Buchert, 1994). In mid 1990s, the government undertook to dev elop the Education Sector Development Programme (ESDP) to tackle the existing problems and face the new challenges emanating from on-going socio-economic reforms initiated earlier and the rising demand for manpower development in line with rapidly transforming technological advancement (Buchert, 1994). The government adopted PRS1 that led to introduction of Complimentary Basic Education in Tanzania (COBET). COBET addresses educational needs for the out-of- school children and youths who
Saturday, November 16, 2019
Eragon The Movie vs. Eragon The Novel Essay Example for Free
Eragon The Movie vs. Eragon The Novel Essay People have different views in life. Some would opt to wallow with the beauty of words and the power of the imagination, while others would opt for movies and witness the wonders of visual effects. Some of the stories made turn out to be inspirations for many, while others become a driving force for people to go on and continue with life. One of the most interesting stories in Literature is Eragon. Due to the story and the lessons that both children and adults would learn, the novel was adapted as a movie into the big screen. However, I believe that the novel version of Eragon is still better than the movie version. THE STORY The story revolves around a young boy, named Eragon, who grew up in a small farm in Carvahall together with his uncle and cousin. During one of his hunting trips in the mountains, he found a big blue stone. The stone attracted him greatly, and Eragon thought that if sold in the city, the stone would be enough to suffice for their winter needs. Unknown to Eragon, the blue stone was actually a dragon egg, ready to hatch. Since care for dragons was prohibited by the king, Eragon had no choice but to secretly raise the poor animal, naming her Saphira. Eventually, they were haunted down by the kingââ¬â¢s men and had no choice but to flee the village. Eragonââ¬â¢s uncle, Garrow, died due to his injuries, making him furious and hungry for revenge. Eragonââ¬â¢s journey towards survival with Saphira led to more secrets. In the course of their adventures, Brom proposed that he would do whatever it takes to help Eragon. The symbol in Eragonââ¬â¢s hand shows that he is indeed one of the dragon riders, like how Brom used to be. Towards the course of the journey, he was transformed from an ordinary teenager to a sword-fighting rider knowledgeable in magic and the ways of Dragon Riders. Eragon meets more people and encounters more life-threatening situations towards the course of the journey, which allows him to learn more about himself. His quest for revenge allowed him to learn more about himself, and how his search for answers would lead him to protect a whole Empire. SIMILARITIES AND DIFFERENCES Books always have their own identity as compared to the film adaptations. This may be attributed to the fact that readers are given the opportunity to view the novel in their own way, and see things according to what their imagination has to offer. The book and film version of Eragon had the same dilemma. Both media had the opportunity to share with people the wonders that Eragonââ¬â¢s life had to offer, and at the same time bring them to a world unknown to many. However, the 2 media used also had their own differences. The film version was intricately made in such a way that the viewers would become curious of what the story has to offer. The special effects used in the film version would definitely come as an impressive work of art. The descriptions set in the book, such as Saphiraââ¬â¢s appearance were perfectly executed in the film. One who has read the book with agree with me, especially in the details set for the other locations in the film. The language used in both versions were also similar with each other. The book on the other hand, made us of too many words. Some of the dialogues and scenes were cut in the film version, somehow giving the viewers a different impression of how the story would go. Take for example Eragonââ¬â¢s journey. Some of the places were deleted, and even Eragonââ¬â¢s reactions towards Katrina were deleted in the film version. In this manner, the plot of the story was somewhat changed deviating from the original context of the novel. PERSONAL ANALYSIS The film version of Eragon was something to be considered. Those who have read the novel would have different impressions about the adaptation, especially when some of the important scenes and dialogues have been deleted. Although the aim of the producers was to fit the whole book in one film, this should have been done using a different approach. In the same manner, I also admire how the visual effects were executed. Saphira was one of the wonders of the whole story, and this was very well presented in the film adaptation. Arya herself was a wonder to marvel at. As the book would have it, she was a beautiful elf, and was supposed to look mysterious at some point in the story. This was done perfectly, and I believe the actress who played her should also be given credit. Unfortunately, the film and the book had so many differences. The film version would look as if it was another story formed from the original novel, and not an adaptation. Although both had considered to keep the plot as the center of the film, the choice of words made the story difficult to absorb. Both readers and viewers would have difficulty in trying to keep in tune with the story because of the many names and places it included. For someone who has seen both media, disappointment would not come as a surprise. However, for those who have not read the book, the film adaptation is impressive, especially with how Saphira was manipulated. Works Cited Eragon. Dir. Stefan Fanmeier. Perf. Jeremy Irons, John Malkovich, Sienna Guillory, Edward Speleers, and Rachel Weisz. 20th Century Fox Home Entertainment, 20 March 2007. Paolini, Christopher. Eragon. Alfred A. Knopf Books for Young Readers, 2003. ââ¬Å"Eragon. â⬠2006. Eragon the Movie. 22 January 2009 http://www. eragonmovie. com/main. html? cid=us. ââ¬Å"Eragon. â⬠The Internet Movie Database. 22 January 2009 http://www. imdb. com/title/tt0449010/. ââ¬Å"Eragon. â⬠Book Browse. 22 Janury 2009 http://www. bookbrowse. com/reviews/index. cfm? book_number=1284. ââ¬Å"Eragon (Inheritance, Book I). â⬠2003. Kids Turn Central. 22 January 2009 http://www. kidsturncentral. com/topics/books/eragon. htm. ââ¬Å"Eragon DVD Review. â⬠22 January 2009 http://www. shurtugal. com/news/comments. php? id=558anum=50.
Thursday, November 14, 2019
Essay --
Robyn Hode Old English folklore dates back to the beginning of American literature. A protagonist among many, Robin Hood (Robyn Hode in Old English manuscript) is introduced into many books and playwrights. Some may argue that Robin Hood's strategies for balancing society were unethical, but this theory could be strongly argued against, and furthermore disproven. Robin Hood could be considered a hero because of his excessive generosity, his ability to see every person as an equal individual, and his overall success to better society. To accurately view Robin Hoods motives, one must look past the rules and laws set aside for the lower class made by ââ¬Å"higher officialsâ⬠, and understand that, even more so in a less developed time period, that right and wrong does not depend on what the rich and powerful say is right and wrong. Robin Hood looked past all of this, identified the true, moral decisions that needed to be made, and took charge. By doing so, and taking a small portion of the rich's wealth and distributing it among the poor, is considered (arguably) one of the most notable heroes of the folklore literary era. In all of the tales written of the infamous Robin Hood, the characteristics illuminated most is his excessive generosity. ââ¬Å"Despite being declared an outlaw, Robin Hood is a good and generous person at heart, and is beloved by the townspeople for his deeds.â⬠(Jurns) While thieving and causing (occasional) mishap, Robyn Hode kept one motive in mind, and that was to take from the undeserving, (fat and rich), and give to the needy, (the poor). This obviously biased by assuming that all the rich are greedy and all the poor are hopeless and deserving. In fact, in most cases people work hard fo... ...orth a sort of balance in society, one in which that needed to be presented. Because all the unfortunate people were too afraid to demand this equality in society, Robin Hood's bravery to go in and fight for what he stood for was admired among the people. This is how he was presented the hero title, and why ballads and playwrights are told about him to this day. Robin Hood's strategy to better the society became a success. By stealing from the rich, to give to the poor, he not only set an example for people to follow his role as a hero, but it also created a balance within the social classes. But today, taxes are distributed among the the country that are arguably fair. In Robin's time, the wealthy placed harsh and unfair taxes among the people, many of them who could not afford to pay them. Failure to pay these taxes resulted in imprisonment, or even worse, death.
Monday, November 11, 2019
Compare Reunion Two Kinds Essay
It often surprises me how different individuals from different cultures and backgrounds all come together in one country and share many experiences. Individuals like Amy Tan who was born among Chinese immigrants, John Cheever from Massachusetts and Louise Erdrich who comes from a Chippewa Indian and German background and was born in Minnesota. A vast variety of origins and they all come to have several good or bad things in common in their work. Hardships of immigration is stated or implied in these pieces as well as parent-child relationship. Nearly all of them carry a sense of determination of different levels and stories of this kind not unlike the ones examined in this piece have a blend, colorless and depressing tone. ââ¬Å"ââ¬Å"Pleading childâ⬠was shorter but slower, ââ¬Å"Perfectly Contentedâ⬠was longer but faster and after I played them both I realized they were two halves of the same songâ⬠(Tan, 105) Now I usually avoid long quotations but this one by Tan should be engraved on gold and kept in the museum of great metaphors. Growing into your long and fast adulthood through your short and slow childhood is indirectly implied throughout Cheeverââ¬â¢s Reunion as well. Here is a confession: When I read that last paragraph of Tans two kinds I got goose bumps. The Last sentence is the strongest and most beautiful ending I have ever read. That moment of clarity was more audible than the construction workers who made it nearly impossible for me to focus on the story as I read it. The Red Convertible on the other hand is of a different style, and looks at the relationship between Henry and Lyman. Two brothers who are in excellent terms and Erdrich emphasizes on that point by mentioning the trust they have for one another. They buy a flashy car together and that is the proof to the argument. A wise man once told me that ââ¬Å"War will burn your soul and from your ashes it shall raise a new personâ⬠. I sensed a close relation to that quote reading Erdrichââ¬â¢s story. As Henry is dramatically changed after witnessing what went down in Vietnam first hand. The most interesting story award by far goes to ââ¬Å"Reunionâ⬠by Cheever. One of the most interesting points in that piece was the fact that the son never showed any disapproval toward his fatherââ¬â¢s behavior no matter how out of line he went. Which implies the conflict the son had inside although never mentioned in the story. The conflict between his pre-approved father as he thinks to himself ââ¬Å"I wish someone saw us togetherâ⬠(cheever, 106) and his own sense of right and wrong. How could someone seem so proper and successful and act like a drunken fool simultaneously . A potion of confusion and amazement that will take him years or decades to digest. Not unlike the confusion that accompanied Jeng mei trough her childhood and teen age. While the undeniable respect for a parent is carved into her brain, she sees her mom as a rival. Preventing all of her be-myself teenage dreams to come true. The tone of a story is like the background music to a scene from a romantic movie. It could either make it or ruin it for the audience. ââ¬Å"Two Kindsâ⬠will bring your eyebrows closer to each other while ââ¬Å"Reunionâ⬠will raise them up to the top of your forehead. ââ¬Å"Two kindsâ⬠takes place in china town ââ¬ânot the best part of New York City ââ¬â . An immigrant mother with broken English who yells at Jeng Mei for every mistake she makes on top of that, is definitely not helping her cause. The story does not calm down until the very end and when it does it is superb. While on the nearly parallel line reunion never changed its tone. It goes from blend to blend. It is amusing all along but it definitely misses a good climax maybe not as exotic as Tanââ¬â¢s but ââ¬Å"And thatââ¬â¢s the last time I saw my fatherâ⬠and the format has ended way too many stories. I see ââ¬Å"Reunionâ⬠by Cheever and Tanââ¬â¢s ââ¬Å"Two Kindsâ⬠as a closer match up and ââ¬Å"The red convertibleâ⬠is just as distant to the rest as its title is. The story still shares the common conflicts but the other two get into much more details and as a reader who has come from a third world country and has seen poverty and prosperity living next door to each other I can very much relate to them.
Saturday, November 9, 2019
Ethical
The problem This paper discusses the legal and ethical implications in conjunction with performing surgery on disabled people for social reasons. Ethical Katie is immaturity and she has the right like other non-disabled girls to live with her body in tact and she has the same choice to give birth to her own baby. According to the Family Court in Australia and Family Law Act 1975, no person under 18 should have hysterectomy unless the procedures are necessary to prevent serious physical and psychological damage and to save life (Skene, 2008, p. 38). Medical This surgery is not medically necessary and it is irreversible, persistent, traumatic and painful that it results in the permanent loss of reproductive capacity. The medical complications after surgery will affect the person health. Social There are lacks of access to health services and recourses, social and educational support for her and her family. Katie is lack of the basic human rights, freedoms to work, freedoms to get educa tion and move freely about society. Legal The parents could not consent and the doctor does not have the right to remove the womb of Katie as non-therapeutic surgery requires court approval. This is not just a medical decision for the doctor, but the childââ¬â¢s best interest and the consequences of wrong decision being made. The facts It is estimated in Australia that a child is born with cerebral palsy every 15 hours. There is no pre-birth test and no known cure for cerebral palsy (Levitt, 2010, p. 33). Cerebral palsy is a permanent physical condition that affects movement. It effects can be just a weakness from one hand ranging to almost complete lack of movement (Miller & Browne, 2005, p. 51). People with cerebral palsy may have seizures and other impairments that affect their speech, vision, hearing or intellect. Spastic, Dyskinetic and Ataxic are the three main types of cerebral palsy. A cerebral palsy result from the neurological damage to the childââ¬â¢s developing brain (Miller et al. , 2005, p. 51). There is greater risk in babies born with low birth weight and preterm. Cerebral palsy can be diagnosed through test reflexes, check for hand preference, CT scan, MRI and Ultrasonography. The treatment are physical therapy which consists exercise to keep limbs from weakening, speech therapy can help regain lost control over facial and throat muscles and gaining the ability to communicate effectively, medication help prevent certain effects of cerebral palsy such as seizures and surgery which is performed to cut some of the nerves affected by spasms and minimize muscle contractions (Miller et al. , 2005, p. 52). Four principles Autonomy Autonomy is described as the right to self-determination, the ability to control what happens to us and how we behave (Staunton & Chiarella, 2003, p. 8). This is a significant ethical principle which allows respect for individuals thought, action and their personal space. Katie is believed to understand little of what is said to her but she has no sense of what is happened to her body. Although, she has the right to make her own decision but she could not give valid consent.. Non-maleficence The principle of ââ¬Ëabove all, do no harm ââ¬â¢ ( Pera & Tonder, 2005, p. 34). A strong principle in health care and it forms the basis of nursesââ¬â¢ duty of care. This procedure affects the welfare and health of Katie as it is seriously invasive her personal integrity and human dignity. Health care professionals should avoid emotional, spiritual, moral and physical harm to Katieââ¬â¢s dignity (Pera et al. , 2005, p. 34). Beneficence The principle of ââ¬Ëabove all, do goodââ¬â¢ (Staunton & Chiarella, 2003, p. 29). It includes the principle of cost benefit analysis and paternalism. In health care, this principle range from determining the number and type of hospital beds in a given geographic area to the validation of research involving human subjects (Pera & Tonder, 2005, p. 4). In Katie case, she deserve better quality of life that she wonââ¬â¢t suffer from menstrual pain, discomfort, mood swings, behavior changes and complication of adulthood. More information about womenââ¬â¢s health nowadays and more alternatives options should be given to her parents so that Katie could receives the best and suitable treatment. Justice The p rinciple of justice is the unifying principle in health and nursing ethics. It comprises the justice as fairness and justice of an equal allocation of burdens and benefits (Staunton et al. , 2003, p. 30). Ethical conflicts This case raises fundamental ethical issue about the way the society treats disabled people and the respect for the human rights and reproductive rights of disabled people. There are a few ethical conflicts arise in Katie case. The conflicts are: is the operation in the best interest of the child, is there any risk of making decision wrongly and is it ethically allows having hysterectomy on disabled people below 18 and without their consent. Menstruation is always regarded negative for parents with disabled kids as it is uncomfortable, unclean and devastating. Therefore, most parents wanted hysterectomy on their disabled kids before their menstruation as they thought their disabled kids would not be able to cope and deal with menstruation. But, it is not known that whether hysterectomy is in the best interest of the child as no one could predicts about the future problems to be encountered with menstruation. This is not fair for the disabled people as they have the rights to experience changes of their body and have their body in tact through their life span (Fellowes, 2000). Sterilization is a serious invasion the person honor and self-respect as their womanhood is being stolen. In 1994, Brennan J, the Chief Justice of the High Court of Australia believed that mentally or physical disabled people should enjoy a full decent life, in condition which ensure dignity, promote self-reliance and participate in the community (Fellowes, 2000). There is a significant risk of making the wrong decision to what are the best interests of a child who cannot consent and the consequences of a wrong decision are grave as this procedure is irreversible and invasive. Cincinnati Adolescent Clinic had carried out an interviewed in 1983, 69 parents were interviewed regarding sterilization of their disabled daughters. Almost 80 percents parents had thought of sterilization and their common reason was to protect their daughters from pregnancy (Strahan, 1991). People with disabilities have the equal human rights as all members of the community (Disability Discrimination Act 1992). Katie has the rights to make her own decision and acknowledge what is happened to her body and health
Thursday, November 7, 2019
10 Facts on Prehistoric Art for a Case Study
10 Facts on Prehistoric Art for a Case Study Before going into the details of the facts to provided here, it is important for us to explore the times before history was actively recorded by discussing the meaning of the word ââ¬Ëprehistoricââ¬â¢. The term prehistoric literally means ââ¬Ëbefore historyââ¬â¢ and it covers the thousands of years before the ancestors of man discovered writing. In prehistoric ages, Homo sapiens made use of art as the only written medium for transferring their thoughts for the sake of posterity. Prehistoric art forms are divided into three distinct eras which are: The Lower Paleolithic: which occurred 500,000 years ago and defines the period when the only art forms of Homo erectus were scratches on cave walls using animal bones. The Middle Paleolithic: this occurred 50,000-100,000 years ago and by then, man had discovered how to draw and paint crudely. The Upper Paleolithic: occurred 10,000-50,000 years ago and is defined as the period man began to paint as well as create figurines and other items for domestic use. This article will attempt to provide 10 facts that cut across the eras explained above which can be used as reference points when writing an essay on prehistoric art. Prehistoric art forms were drawn for definite purposes and these purposes were generally ritualistic and to glorify the hunt. Other prehistoric drawings depicting seasonal animals were also attempts by prehistoric man to document the seasons as they came and went. Prehistoric men truly resided in caves and carried out most of their activities in hiding. This is due to the fact that they hid from predators as well as the ever changing elements of nature. Although prehistoric men drew on sand and rocks, the ravages of time eclipsed these drawings and we have only the cave art to tell us about their culture. Prehistoric artist actively believed that depicting an object or item in art form was a way of putting a binding spell on the drawn item. Therefore while they drew animals in clear details to cast hunting spells on the animals, they abstained from drawing exact depictions of themselves in order not to create binding spells. Although the belief in one Supreme Being would come later in time, prehistoric humans believed in hunting gods and fertility goddesses as can be seen in their works of art Prehistoric Drawing and Painting Materials: the art forms in the middle and upper Paleolithic era were much more developed than the bone pickings and scratches of the lower Paleolithic era. Prehistoric artists made use of their fingers, bird feathers and animal bones as drawing tools. While for painting, prehistoric artist took advantage of the different types of clay to produce red, brown and yellow colors. And for black, charcoalà and mud mixed with cave water was used in creating the color black. Prehistoric Art and Painting Techniques: while most people associate prehistoric art with the backwardness of the cave man, prehistoric art shows otherwise. In the caves of La Vache, archaeologists discovered charcoal tracings underneath the animal paintings depicted on its walls. This showed advanced drawing techniques such as sketching to achieve accuracy. Also, hollowed bones and feathers were used as painting tools which goes to show the advanced spray painting techniques used in prehistoric art. Prehistoric Art, Sculpture and the Pictures Depicted: studies show that earlier art forms from the prehistoric era were usually drawings or animals with arrows or spears in them while humans were hardly featured till later in the middle Paleolithic. So prehistoric art forms contained mainly animals such as Bison, cattle, reindeer, mammoths and aurochs. Further analysis of prehistoric art forms showed that 75% of these art works were created by hunters while a mere 15% were created by gatherers. Human sculptures and art works began to feature in prehistoric art during the upper Paleolithic period in the form of stick sketches and the Venus figurines. Prehistoric Art and Location: prehistoric art works have been unearthed in caves and archaeological sites all over the world but the most notable mentions are:South Western France and Northern Spain which are home to over 350 sites where cave paintings have been discovered. Prehistoric art works from these regions are jointly known as Franco-Cantabrian cave art. Other notable mentions are southwestern Germany, South Africa, India and China. Where are the Oldest Cave Paintings Located? Radiocarbon dating techniques have been applied to most cave paintings found across the globe to determine their ages and the facts show that: El Castillo cave paintings in Cantabria Spain are the oldest paintings that have been discovered to date. Its age is set at approximately 39,000 BCE. Next is the Leang Timpuseng cave in Indonesia which is dated to have been painted in 37,500 BCE. Third is the Chauvet cave in France created around 30,000 BCE. Prehistoric Art and Sexual Depictions: although it took a while for prehistoric artists to start depicting humans in their paintings and sculptures, early figurines showed that the female form were more popular objects of interest than the male form. These early sculptures of women figures always followed the artistic format of a large breasted woman with protruding stomach and hip regions. They might have been viewed as sexual in this modern age. Prehistoric Art included Sculpture: Although most art works from the prehistoric age were cave drawings and paintings, the middle and lower Paleolithic age witnessed the inclusion of sculpting as a means of creating art in prehistoric times. Bas-relief techniques were used in creating sculptures as can be seen from the Venus of Laussel sculpture and prehistoric artist made use of limestone and unfired clay in sculpting these objects. Here is where we come to the end of the cool facts on prehistoric art works which can be used when drafting case study on prehistoric art. These facts were provided to aid your research and writing process if giving such a project. So do not hesitate to use them as reference points where and when the need may arise. Additionally donââ¬â¢t hesitate paying a visit to our 20 topics for a case study on prehistoric art as well as our genre specific guide. References: Wikipedia: Prehistoric Art.à https://en.wikipedia.org/wiki/Prehistoric_art Visual Art Encyclopedia: Prehistoric Art of the Stone Age.à visual-arts-cork.com/prehistoric-art.htm Francis, G. (2007). Religious Awareness in Art Forms from Prehistory to Today 3-5à crossroadsnyc.com/files/Greene_CaveArt.pdf Laura, T. (2007). Introduction to Prehistoric Art, 20,000-8,000 B.C.à metmuseum.org/toah/hd/preh/hd_preh.htm Kiaren, J. (2005). Female Figurines of the Upper Paleolithic.à ancient-origins.net/ancient-places-europe/venus-figurines-european-paleolithic-era-001548 Alan, D. (). Venus Figurines of the European Paleolithic: Symbols of Fertility or Attractiveness?à ancient-origins.net/ancient-places-europe/venus-figurines-european-paleolithic-era-001548 Soffer, O. Adovasio, J. (2000). Textiles, Basketry, Gender and Status in the Upper Paleolithic.à unl.edu/rhames/courses/current/venus1.pdf
Monday, November 4, 2019
Branding britian Research Paper Example | Topics and Well Written Essays - 500 words
Branding britian - Research Paper Example The IMC dimensions in the video advert on Great Britain include the voice, the interactions as well as the lucrative nature of the long term relationships formed. Also included is the exploration of the highlight using the IMC Development theoretical model. This involves looking at the orientation of the brand, the promotion, the end results of the brand, as well as the financial end results (Moriarty, 2012). For instance, our report talks about the sounds of Britain that have been known to define the tourism sector greatly. Such include the ticking of the clock, the mixing of tea and coffee, the passing of trains and cars, ringing of bells and cheering of games by fans. Using one voice means bringing together the marketing objectives with only the intention of directing the audience towards the objective of the promotion. According to (Moriarty, 2012), having one voice is very crucial, and it means that the communication instruments used have been able to convey clear ideas to its audience. The written texts displayed coincide with the pictures provided. The graphics, for instance, at the beginning of the video whereby there is a display of the Great Britain airports with visitors checking in balances with the simultaneous written message about the increase in visitor spending. This is seen during the first 20 seconds into the video, in which there is a narration of a story of a boy who travelled to a faraway place, but there is no link provided between this and the overall marketing objective. This is the same for the mention of the land rover defender, halfway into the video without mention of its relevance. On the other hand, having the intervie ws towards the end of the video has successfully avoided overloading the audience with information. Interactivity improves communication as part of marketing by making it possible for the audience
Saturday, November 2, 2019
ANALYSING A SPREADSHEET AND PRESENTING A BUSINESS REPORT Case Study
ANALYSING A SPREADSHEET AND PRESENTING A BUSINESS REPORT - Case Study Example From the reference data provided by the business, there are 4 types of fruit juices that are available for sale. Each type of juice has two variances in size, one in 375ml and another in 750ml. According to the sales calculations presented in the spreadsheet charts, the fruit juices differ in the number of sales they attract. The variance could be mainly due to, popularity of a type of fruit juice among buyers or the price per carton for each. However, various factors may apply depending on the market of operation for the business. By comparing the pivot table charts against the sales calculations over the five weeks, orange and mandarin are seen to have higher sales. As the weeks progress, sales for the two types of fruit juices are seen to project further than the other two. This shows that mobile app based marketing was more acceptable as compared to emails and or texts. Unlike the emails or texts, the mobile apps presented more benefits to the retailers buying the fruit juices. That is, a retailer would be able to plan a reminder, place an order and track customer orders right from their smartphones. Emails and texts, on the other hand, would only serve the purpose of acting as reminders. If not spread out proportionally, the emails and text messages would easily become nagging and stubborn to the retail buyers. From the charts, the buyers would prefer being reminded through a smartphone mobile app. In the fourth week marketing strategy, a two-for-one strategy was introduced on mandarin fruit juice. From the pivot table, the sales for the mandarin fruit juice are seen to consistently increase from the second week: Little change is seen on the sales at the fourth or fifth week. A further look at the sales for mandarin juice reveals that, though the product made more sales that apple and grapefruit juice, it was selling below par. That is, the two-for-one policy did not impact the sales upwards as would be expected. Reason
Thursday, October 31, 2019
Daydreamer Essay Example | Topics and Well Written Essays - 1250 words
Daydreamer - Essay Example I was happy about that, because I felt smarter, like I was a more rational person. Unfortunately, I started to realize that as logic and rationality were building up in my mind, imagination was flowing out. The day that I first really noticed that this was happening, I was at my cousinsââ¬â¢ house. We were hanging out and telling ghost stories, just like we had a long time ago, when we were just kids and really believed all the stories we told. The day before, I had been trying to write a story. I stared at my computer screen, but I could not dredge up one single good idea from the depths my mind. I slapped the lid of my laptop shut with disgust and tried to think about other things, thinking that an idea would come floating into my head when I wasnââ¬â¢t reaching out for it so desperately. Now, at my cousinsââ¬â¢ house, we were talking about all the ghosts we used to believe in. We talked like we all still believed, though. At least, my cousins did. They talked about all th e hauntings and the ways we used to scare ourselves like it was real. I kind of nodded and laughed along with them, not sure if we were playing a game for the sake of old-times, or if they really meant it. One of my cousins, Sam, brought up the story of Adrian, a ghost we used to think haunted our grandparentsââ¬â¢ house. We used to convince ourselves that every little sound or shadow was Adrian. We even made a little spinner, like a spinner from a board game, with a tack and a cardboard arrow that we could flick to make it twirl around and point to words weââ¬â¢d written on a piece of paper. ââ¬Å"Yes / No / Maybeâ⬠were the words weââ¬â¢d scrawled in our big round kidsââ¬â¢ handwriting. ... next to an open window, and all say together, ââ¬Å"Adrian, Adrian, are you there?â⬠If nothing happened (and nothing usually did), we would go off and play, and come back and check on the spinner to see if it had moved. If it was pointing to ââ¬Å"yes,â⬠we would start running around, giggling and screaming. The rare times when there was a breeze right at the time we said our little chant, and the spinner moved right before our eyes, we would completely freak out, no matter which of the words it was pointing to. ââ¬Å"Yesâ⬠meant ââ¬Å"yes,â⬠and ââ¬Å"maybeâ⬠meant yes, but he was being coy with us. ââ¬Å"Noâ⬠naturally meant there was some other ghost hanging around; perhaps a more sinister one than Adrian. That day we sat at the kitchen table, drinking Cokes and laughing about what silly kids we used to be, but when my cousins talked about Adrian, it was with total seriousness. ââ¬Å"Remember the time he pulled the blankets down on my bed?â⠬ Sam asked. ââ¬Å"Oh yeah!â⬠said Dana. ââ¬Å"Or when he knocked down that statue of a brass cat that Grandma used to have on the shelf?â⬠I couldnââ¬â¢t stand it anymore. Were they serious? ââ¬Å"Guys,â⬠I said. ââ¬Å"You know Adrian wasnââ¬â¢t real, right? You know that that statue could have fallen down for a lot of different reasons, and you probably half-dreamed your blankets being pulled off when they really just fell. Tell me you donââ¬â¢t still believe in Adrian.â⬠ââ¬Å"No way!â⬠Dana shook her head. ââ¬Å"Thereââ¬â¢s no way that statue could have just fallen down by itself. It was way back on the shelf. And I know Sam wasnââ¬â¢t dreaming about the blankets. Tell the story, Sam.â⬠Sam stared at me like he thought I had lost my mind. ââ¬Å"I was sleeping at Grandmaââ¬â¢s house one night, and I woke up and couldnââ¬â¢t move. I felt this presence in the room with
Tuesday, October 29, 2019
International Business Country Analysis - South Korea Essay
International Business Country Analysis - South Korea - Essay Example After the Korean War (1950-1953), South Korea rose from devastation to become one of the worldââ¬â¢s largest economies in the 1990s. South Korea occupies the southern half of the Korea Peninsula, which extends about 1,000 km (about 620 mi) southward from northeastern China. The total area of South Korea is 99,268 sq km (38,328 sq mi), including about 3,000 islands. South Korea is a mountainous country. Lowlands, located primarily in the west and southeast, constitute only 30 percent of the total land area. South Korea can be divided into three general regions: an eastern region of high mountain ranges and narrow coastal plains; a western region of broad coastal plains, river basins, and rolling hills; and a southern region, where a maze of mountains and valleys in the west contrasts with the broad basin of the Nakdong River in the southeast. Historically, Korea was strongly influenced by Chinese culture and acted as a conduit of culture from China to Japan. Koreans adapted many Chinese art forms with innovation and skill, creating distinctively Korean forms. For many centuries, metalwork, sculpture, painting, and ceramics flourished throughout the Korea Peninsula. Buddhism provided one of the most significant sources for artistic expression. Confucianism, also prominent, emphasized the importance of literature and calligraphy, as well as portrait and landscape painting. Koreans began to incorporate Western forms after Korea opened itself to the Western world in the late 1800s. During the period of Japanese colonial rule (1910-1945), indigenous traditions were strongly discouraged. Since then, however, Koreans have made a concerted effort to keep their cultural traditions alive. Koreans possess a deep appreciation for their cultural heritage. The government encourages the traditional arts, as well as modern forms, through funding and education programs as well as sponsorship of a national
Sunday, October 27, 2019
Distinct Serum Protein Pattern in Paranoid Schizophrena
Distinct Serum Protein Pattern in Paranoid Schizophrena A DISTINCT SERUM PROTEIN PATTERN IN PATIENTS WITH PARANOID SCHIZOPHRENIA[A1] N. A. Timofeyeva1,3, I. V. Alekseeva1,3, S. A. Ivanova2,4, G. G. Simutkin2, A. V. Semke2, I. S. Losenkov2, N. A. Bokhan2, O. S. Fedorova1,3, A. A. Chernonosov1,3* 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia 2 Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia 3 Novosibirsk State University, Novosibirsk, Russia à à 4 National Research Tomsk Polytechnic University, Tomsk, Russia ABSTRACT The proteomic approach, namely, a combination of 2D gel electrophoresis and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry, is a powerful tool that allows researchers to identify proteins that are differentially expressed in disease states. Schizophrenia is a chronic mental illness, whose aetiology is still unclear; therefore, information about differences in serum protein patterns may improve the understanding of the pathophysiology of schizophrenia. The goal of this study was to use the proteomic approach to identify altered protein levels in the serum samples from patients with schizophrenia. For this study, blood was collected from 10 patients with paranoid schizophrenia and 10 healthy volunteers. We uncovered major changes in the expression of such proteins as apolipoproteins of classes A4 and C3, transthyretin (TTR), and serum amyloid A1. Furthermore, an increase in expression was found only for apolipoprotein A4, whereas the expression of apolipoprotein C3, TTR, and serum amyloid A1 was decreased. The observed differences in the expression of serum proteins (TTR and serum amyloid) are in good agreement with the results obtained by other research groups during analyses of cerebrospinal fluid or post-mortem brain tissues by other methods. Keywords: psychiatric disorder, schizophrenia, [A2]à proteomics, 2D electrophoresis, MALDI-TOF mass spectrometry, biomarker, serum. Introduction Although in recent years, great progress has been made in reducing mortality and in the treatment of common illnesses such as cancer and cardiovascular disease, the mortality caused by mental disorders remains unchanged [1]. Schizophrenia is a chronic mental illness, whose aetiology is still unclear. Schizophrenia is characterised by hallucinations, delusions (positive psychotic symptoms), affective problems [A3](negative psychotic symptoms), and cognitive dysfunction [2]. A number of hypotheses have been proposed about the pathogenesis of schizophrenia, for example, aberrations [A4]à in the pathways of transmission of neurotransmitters dopamine and serotonin [3, 4] or pathological changes in embryonic neurogenesis owing to variations in gene neuregulin-1 [5], as well as oxidative-stress-mediated cell damage due to lowered levels of antioxidant defence enzymes in patients with schizophrenia[A5] [6]. Such pathogenesis may be caused by a dysfunction of some enzymes (proteins) as well as changes of their quantity in the blood of these patients. At the same time, there is no information about differences in serum protein patterns that can be used for typing of psychopathologies among individuals at risk of developing psychiatric disorders [7]. Diagnosis and nosology rely on symptoms and accumulated clinical observations, and thus far, have been based mostly on interviews with patients and on patients subjective complaints [8]. Moreover, current medications still have substantial adverse effects and/or require weeks for therapeutic effects to manifest themselves; not all patients respond to current pharmacotherapy [9]. In sum, an insufficient understanding of psychiatric disorders at the molecular level and the lack of disease-specific changes in serum protein patterns prevent optimisation of diagnosis and treatment of such complex psychiatric disorders as schizophreniaà [A6]. The proteomic approach, namely, the combination of 2D gel electrophoresis and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS), allows researchers to reliably identify proteins isolated from human bodily fluids [10, 11]. Our exploratory study [12] showed that 2D gel electrophoresis is suitable for isolation of proteins from blood of patients with mental disorders. Thereforeà [A7], in the present work, clinical blood samples from patients with a diagnosis of schizophrenia were tested to identify quantitative differences in the proteomic profile of serum. Results and Discussion In this study, we examined blood serum of healthy people and patients with paranoid schizophrenia to search for quantitative and/or qualitative differences in proteins associated with this mental disorder. The use of 2D gel electrophoresis enables researchers to simultaneously isolate more than 300 protein spots on one gel containing 150 à µg of protein for subsequent MALDI-TOF MS/MS analysis [10, 11]. We analysed differences in serum protein patterns by comparing the gels between the patients and healthy controls. The analysis [A8]à of protein patterns in serum was focused on those protein spots that differed in 2D gels between the patients and healthy controls. Such protein spots were analysed by means of the Gel-Pro Analyzer software and normalised to the sum of three proteins (a, b, Ãâà ; for details, see Materials and Methods). These three proteins are isoforms of apolipoprotein L (ApoL) [18]. As a result, 15 protein spots were isolated and identified by peptide mass fin gerprinting and MS/MS analysis. The list of proteins identified in the NCBI database is shown in table [A9]1. Some proteins haptoglobin, transthyretin (TTR), and apolipoprotein C3 shown in table 1 are present in more than one spot on a gel and have different pI values. Perhaps this phenomenon is due to various post-translational modifications or partial processing. It was found that only the serum level of ApoA4 was increased (1.8-fold) as compared to the control group (figure 1a). Our findings support other [A10]à reports on altered protein levels in serum and cerebrospinal fluid in schizophrenia [19, 20]. à à The decrease in the serum concentration relative to the control group was observed for ApoC3 and for ApoC2 in patients with schizophrenia (figure 1b). This downregulation was on average from 1.8- to 3-fold for ApoC3, and smaller for ApoC2: only 1.25-fold. These proteins are synthesised in the liver and are components of very low-density lipoproteins (VLDLs). Apolipoprotein C2 activates extrahepatic lipoprotein lipase, whereas apolipoprotein C3 can inhibit lipoprotein lipase Fig. 1 Examples of proteins with differential expression in human serum are presented in the enlarged sections of the 2DE profile. a) Apo A4; b) Apo C3 and C2; c) serum amyloid A1; d) transthyretin (the protein is present in two spots because of post-translational modifications). Sch: schizophrenia. and activate LCAT [21, 22]. Previously, it was found that the expression of apolipoproteins is altered in schizophrenia, bipolar disorder, and other psychiatric disorders [23]. The authors found that low-density lipoproteins (LDLs) and VLDLs are the most prominent factors differentiating depressed patients from healthy controls, and that plasma unsaturated lipid concentrations are elevated in the depressed group. Thus, there is growing evidence that deregulated lipid homeostasis may play a common role in the pathophysiology of psychiatric disorders such as schizophrenia. Other proteins with a decreased concentration are serum amyloid A1 and TTR (figure 1c and 1d). Inflammatory amyloid A1 is among the so-called acute phase proteins, which have both direct and indirect bactericidal and/or bacteriostatic properties. According to the classical theory of inflammation, in the acute phase of inflammation, the serum concentration of amyloid A1 increases 100- to 1000-fold [24], whereas in our study, we observed a 2.3-fold decrease in the serum concentration of this protein in patients with schizophrenia. Perhaps this resultà [A11] is due to decreased immunity in Table 1. The list of proteins from human serum analysed by 2DE and identified by MALDI-MS/MS after in-gel digestion with trypsin. Protein NCBI database no. Protein ID pI MW (kDa) Score (individuals/ significant) Fold Change (+/-)* Sch vs control 1 gi157831596 ÃŽà ±2-antitrypsin 5.37 44.3 48/45 -1.32 à ± 0.2 2 gi338305 SP 40 5.74 36.7 17/10 -1.31 à ± 0.09 3 gi3337390 Haptoglobin 6.14 38.2 35/29 +1.22 à ± 0.13 4 gi114318993 Transthyretin (dimer) 5.16 20.2 120/84 -1.68 à ± 0.25 5 gi11957960 Apolipoprotein A4 5.28 28.9 43/32 +1.84 à ± 0.16 6 gi223976 Haptoglobin hp2ÃŽà ± 6.23 41.7 39/20 -1.38 à ± 0.17 7 gi296653 Haptoglobin hp2ÃŽà ± 6.23 41.5 18/10 -1.42 à ± 0.11 8 gi296653 Haptoglobin hp2ÃŽà ± 6.25 41.5 39/15 -1.56 à ± 0.24 9 gi4507725 Transthyretin 5.52 15.9 75/52 -1.06 à ± 0.13 10 gi4507725 Transthyretin 5.52 15.9 65/60 -1.45 à ± 0.23 11 gi4557323 Apolipoprotein C3 5.23 10.8 112/70 -1.85 à ± 0.21 12 gi4557323 Apolipoprotein C3 5.23 10.8 115/68 -3.28 à ± 0.16 13 gi4557323 Apolipoprotein C2 5.42 11.2 104/78 -1.25 à ± 0.08 14 gi40316910 Serum amyloid A1 6.28 13.5 134/90 -2.34 à ± 0.09 15 gi19626079 Albumin fragment 6.20 22.4 56/40 -2.06 à ± 0.32 The fold change is equal to SPi/SPcontrol, where i is the identification number of a spot. Symbols - and + mean a decrease and increase, respectively. Sch: schizophrenia. patients with psychiatric disorders or to the presence of comorbidities. In addition, [A12]à it is possible that a decrease in serum amyloid A1 concentration is related to downregulation of antioxidant-defence enzymes in patients with schizophrenia [6] because high-density lipoproteins (HDLs) inhibit oxidative modification of LDLs via the activity of their associated enzymes and apolipoproteins [25]. If HDLs become so-called dysfunctional HDLs because of accumulation of oxidants derived from an inflammatory reaction, such HDLs inhibit the HDL-associated antioxidant enzymes and reduce the ability of apolipoproteins A1 to promote ABCA-1-mediated cholesterol efflux [25]. In the literature, there are data on a strong positive relation between cholesterol levels and pathophysiological features of mood disorders. The link between mental health (brain) and cholesterol is believed to be based on hypothetical neuron-associated mechanisms. Cholesterol is an integral component of the plasma m embrane of neurons and is present in myelin. Furthermore, cholesterol performs crucial functions in the development, stability, and workings of the synapse [26]. Overall, aberrations in cholesterol in a psychiatric illness may substantially affect the mood via synaptic stability and lowered serotonergic activity. In the case of TTR, we observed a decrease in the serum concentration of its dimer and one of monomeric forms (protein 10 in Table 1) among the patients with schizophrenia (~1.7-fold and ~1.5-fold, respectively), whereas the serum level of another TTR monomeric form was found to be unchanged relative to the control group (protein 9 in Table 1). TTR is a liver-derived secretory protein and is the major serum carrier of thyroid hormones: thyroxine and tri-iodothyronine. TTR is also involved in the transport of retinol via an interaction with retinol-binding proteins. Several studies were conducted in an attempt to identify disease biomarkers that could advance the understanding of the pathogenesis of schizophrenia. In some of these studies, a link between TTR and schizophrenia was found [27, 28]. In ref. [28], it was estimated that 3% of TTR in ventricular cerebrospinal fluid [A13]à and 10% of TTR in lumbar cerebrospinal fluid are derived from blood. To assess the involvement of blood TTR in the changes observed in the cerebrospinal fluid of patients with schizophrenia, those authors also studied serum TTR levels in the same people (simultaneously with cerebrospinal fluid collection) by an ELISA. They observed a significant moderate decrease in TTR concentration in serum samples of patients with schizophrenia compared to co ntrols. Nevertheless, there was no association between cerebrospinal-fluid and serum TTR levels in the same individuals, indicating that the protein levels of TTR are regulated by different systems in serum and in cerebrospinal fluid. Conclusion In the present study, we identified differentially expressed proteins in the serum from patients with schizophrenia by proteomic analysis. We showed differential expression of such proteins as TTR, serum amyloid A1, and apolipoproteins of classes A4 and C3. Furthermore the increase in the expression was found only for apolipoprotein A4, whereas the expression of apolipoprotein C3, TTR, and serum amyloid A1 was decreased. Such alterations of the expression of these proteins may indicate problems with regulation, for example, in the synthesis. On the other hand, the altered protein expression may simply reflect the pathophysiological status of patients with schizophrenia, where these proteins could be candidates for biomarkers.à Nevertheless, to confirm the significance of the altered levels of these proteins in the pathogenesis [A14]à of schizophrenia, and to determine their suitability as biomarkers of schizophrenia, further research is needed. Competing interests. The authors declare that they have no conflicts of interest related to the contents of this article. Funding. This research was made possible in part by a grant from the Russian Science Foundation (14-15-00480, with the exception of the work corresponding to MALDI-TOF MS/MS analysis) and Federal Agency for Scientific Organizations (the part of work corresponding to MALDI-TOF MS/MS analysis). References Kessler RC, Demler O, Frank RG, Olfson M. 2005 Prevalence and treatment of mental disorders 1990 to 2003. N. Engl. J. Med. 352, 2515-2523. J. van Os, S. Kapur Schizophrenia. Lancet (Lond. Engl.), 374 (2009), pp. 635-645 H. Moore, A.R. West, A.A. Grace. The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol. Psychiatry, 46 (1999), pp. 40-55. M.A. Geyer, F.X. Vollenweider. Serotonin research: contributions to understanding psychoses. Trends Pharmacol. Sci., 29 (2008), pp. 445-453. E. Bramon, E. Dempster, S. Frangou, M. Shaikh, M. Walshe, F.M. Filbey, C. McDonald, P. Sham, D.A. Collier, R. Murray. Neuregulin-1 and the P300 waveform-a preliminary association study using a psychosis endophenotype. Schizophr. Res., 103 (2008), pp. 178-185 P.K. Ranjekar, A. Hinge, M.V. Hegde, M. Ghate, A. Kale, S. Sitasawad, U.V. Wagh, V.B. Debsikdar, S.P. Mahadik. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res., 121 (2003), pp. 109-122. Ivanova SA, Fedorenko OYu, Smirnova LP, Semke AV. 2013 Biomarker discovery and development of pharmacogenetic approaches to personalized therapy of patients with schizophrenia. Siberian vestnik of psychiatry and narcology. 12-16. Turck CW, Maccarrone G, Sayan-Ayata E, Jacob AM. 2005 The quest for brain disorder biomarkers. J. Med. Invest. 52, 231-235. Bystritsky A. 2006 Treatment-resistant anxiety disorders. Mol. Psychiatry. 11, 805-814. Davalieva K, Kostovska IM, Dwork AJ. 2016 Proteomic research in schizophrenia. Front. Cell. Neurosci. 16, (doi: 10.3389). Guest PC, Guest FL, Martins-de Souza D. 2016 Making sence of blood-based proteomics and metabolomics in psychiatric research. Int.J. of Neuropsychopharmacology. 719-728. Alekseeva IV, Timofeeva NA, Chernonosov AA, Ivanova SA, Bokhan NA, Fedorova OS. 2013 Use of two-dimensional electrophoresis for proteomic studies of serum from patients with mental disorders. Vestnik of Novosibirsk State University. Series: Biology, Clinical Medicine. 11, 56-60. PeÃâ¦Ã ¡iÃââ⬠¡ I, Dihazi GH, Mà ¼ller GA, Jahn O, Hoffmann M, Eltoweissy M, Koziolek M, Dihazi H. 2011 Short-term increase of glucose concentration in PDS results in extensive removal and high glycation level of vital proteins during continuous ambulatory peritoneal dialysis. Nephrol. Dial. Transplant. 26, 2674-83. Giuliano S, Agresta AM, De Palma A, Viglio S, Mauri P, Fumagalli M, et al. 2014 Proteomic Analysis of Lymphoblastoid Cells from Nasu-Hakola Patients: A Step Forward in Our Understanding of This Neurodegenerative Disorder. PLoS ONE. 9(12): e110073. (doi:10.1371/journal.pone.0110073). Candiano G, Bruschi M, Musante L, Santucci L, Ghiggeri GM. 2004 Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis. 25, 1327-1333. Brauner JM, Groemer TW, Stroebel A, Grosse-Holz S, Oberstein T, Wiltfang J, Kornhuber J, Maler JM. 2014 Spot quantification in two dimensional gel electrophoresis image analysis: comparison of different approaches and presentation of a novel compound fitting algorithm. BMC Bioinformatics. 15, 181-193. Perkins DN, Pappin DJ, Creasy DM, Cottrell JS. 1999 Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis. 20, 3551-3567. Lepedda AJ, Nieddu G, Zinellu E, De Muro P, Piredda F, Guarino A, Spirito R, Carta F, Turrini F, Formato M. 2013 Proteomic analysis of plasma-purified VLDL, LDL, and HDL fractions from atherosclerotic patients undergoing carotid endarterectomy: identification of serum amyloid A as a potential marker. Oxidative Medicine and Cellular Longevity. 2013, 1-11. Aphkhazava D, Nieves E, Callaway M, Olszewski W, Rotzschke O, Santambrogio L. 2013 Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. J Proteomics. 78, 172-187. Wan CLa Y, Zhu H, Jiang L, Chen Y, Feng G, Li H, Sang H, Hao X, Zhang G, He L. 2007 Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene.Amino Acids Amino Acids 1, 101-108. Eckel RH. 1989 Lipoprotein lipase: a multifunctional enzyme relevant to common metabolic diseases. N.Eng.J.Med. 320, 1060-1068. Wang HEckel RH. 2009 Lipoprotein lipase: from gene to obesity. Am. J. Physiol. Endocrinol. Metab. 297, 271-288. Zheng P, Gao HC, Li Q, Shao WH, Zhang ML, Cheng K, Yang de Y, Fan SH, Chen L, Fang L, Xie P. 2012 Plasma metabonomics as a novel diagnostic approach for major depressive disorder. J. Proteome Res. 11, 1741-8. doi: 10.1021/pr2010082. Baumannà H. 1994 The acute phase response. J. Gauldie: Immunologie Today. 2, 74-80. Vohnout, B., de Gaetano, G., Donati, M. B. and Iacoviello, L. (2011) The Relationship between Dyslipidemia and Inflammation, in Nutritional and Metabolic Bases of Cardiovascular Disease (eds M. Mancini, J. M. Ordovas, G. Riccardi, P. Rubba and P. Strazzullo), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318456.ch26 Chattopadhyay A, Paila YD. 2007 Lipid-protein interactions, regulation and dysfunction of brain cholesterol. Biochem. Biophys. Res. Commun. 16, 627-33. Wan C, Yang Y, Li H, La Y, Zhu H, Jiang L, Chen Y, Feng G, He L. 2006 Dysregulation of retinoid transporters expression in body fluids of schizophrenia patients. J. Proteome Res. 5, 3213-3216. Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S. 2006 Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis. PLoS Med. 3, (e428). [A1]Dear Author, Please dont forget to update the title in all supporting documents and correspondence. It often happens that after the language editing, coauthors make additions to the manuscript; also, some of the corrections are rejected. As a result, the manuscript that is submitted to the journal may contain 5-10 new errors. My advice is to send me the manuscript for a quick check on the day of the submission to the journal. I can use the automatic compare documents function of Word to find all new changes and to correct them quickly. I will also issue a certificate after this final check, and you can insert the sentence (optional) The English language was corrected and certified by shevchuk-editing.com. into Acknowledgments. [A2]Please do not include keywords that other researchers are unlikely to use when searching for articles. [A3]Affective disorders are depression and bipolar disorder. [A4]Please be careful with the words abnormal and abnormality when referring to a persons health status because they may be insulting to patients. [A5]Please note that this is a more polite form. [A6]Please avoid creating unusual abbreviations and single-word abbreviations because they make a text harder to read (well-known abbreviations such as DNA and official gene symbols are OK). The only valid reason for creating an abbreviation is the following: a long multiword expression (4 or more long words) that occurs more than 4 times in the text. Even in this case, it is better to avoid abbreviating. It is easy to write in abbreviations but it is difficult to decipher such a text. [A7]Please avoid creating long sentences because they are hard to read. [A8]Please note that the word study usually means the whole manuscript. [A9]The typical format is Table [A10]Please keep in mind that the word previous is redundant in this context because all published studies are previous. It is OK to say previous when you discuss your own earlier studies. [A11]Please dont use the words which or this as a substitute for the whole sentence or a statement. This usage is vague and confusing because some people will think that this or which refers to the last word, not the whole statement. Therefore, it is better to use a descriptive phrase instead. [A12]Its not a good idea to start a sentence with such words as and, but, also, or, so in a formal text. [A13]Please dont create abbreviations at the end of the article, after the full form was already used many times. [A14]= mechanism
Subscribe to:
Posts (Atom)